If you don't already have it done, download and install "Point Blank" Menu option at left. Use the ballistics for your round to derive the trajectory. Now comes decision time.
If you are hunting use the maximum point blank range, which is calculated by the program, as your zero, just as Elvis has indicated above. If you are punching paper use your normal target range.
If you are using a scope with graduations you can zero so the graduation above your crosshair is at your paper target range and then you will know, again using "Point Blank", where a crosshair hold will give you your next "Zero".
If you are using several loads then plot the trajectory of each and choose a zero that minimizes the difference over the range of loads over the distances you normally shoot. Again "Point Blank" allows you to plot each trajectory and diisplay the plots in one graph. Choosing the best zero becomes much easier than crunching numbers yourself.
I don't have "Point Blank" installed on my tablet or I would post an example of the graph for a selection of commercial loadings in your caliber.
Wikipedia on Trajectory